Protein A
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Official Full Name
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Overview
Protein A is a 56 kDa MSCRAMM surface protein originally found in the cell wall of the bacterium Staphylococcus aureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two-component system called ArlS-ArlR. It has found use in biochemical research because of its ability to bind immunoglobulins. It is composed of five homologous Ig-binding domains that fold into a three-helix bundle. Each domain is able to bind proteins from many of mammalian species, most notably IgGs. It binds the heavy chain with the Fc region of most immunoglobulins and also within the Fab region in the case of the human VH3 family. Through these interactions in serum, where IgG molecules are bound in the wrong orientation (in relation to normal antibody function), the bacteria disrupts opsonization and phagocytosis. -
Synonyms
Immunoglobulin G binding protein A protein;SPA protein;Staphylococcal protein A protein;SpA;56 kDa MSCRAMM;ProteinA;PROTEIN A;Staphylococcal protein A;IgG binding protein A;SAOUHSC_00069;Immunoglobulin G binding protein A;gG-binding protein A
Recombinant Proteins
- Bacterial
- Staphylococcus aureus
- Staphylococcus
- E.coli
- E. coli or Yeast
- E. coli
- His
- Non
- His&Biotin
Involved Pathway
Protein A involved in several pathways and played different roles in them. We selected most pathways Protein A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Protein A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
Protein A has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Protein A itself. We selected most functions Protein A had, and list some proteins which have the same functions with Protein A. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
Protein A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Protein A here. Most of them are supplied by our site. Hope this information will be useful for your research of Protein A.
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References
- Al-Bahrani, R; Tuertcher, D; et al. Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:3-9(2015).
- Yang, YR; Feng, JD; et al. Immune Responses to a Recombinant Rv0057-Rv1352 Fusion Protein of Mycobacterium tuberculosis. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:39-48(2015).
